Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An interactive computer program for the analysis of growth curves.

S Guo, R Simon, J E Talmadge

    Computers and Biomedical Research, an International Journal
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mitigation of microbial contamination from waste water and aerosolization by sink design.

    The Journal of hospital infection·2019
    Same author

    Lenalidomide and cyclophosphamide immunoregulation in patients with metastatic, castration-resistant prostate cancer.

    Clinical & experimental metastasis·2015
    Same author

    Cryopreservation of adenovirus-transfected dendritic cells (DCs) for clinical use.

    International immunopharmacology·2012
    Same author

    Lymphocyte subset recovery following allogeneic bone marrow transplantation: CD4(+)-cell count and transplant-related mortality.

    Bone marrow transplantation·2007
    Same author

    Spleen but not tumor infiltration by dendritic and T cells is increased by intravenous adenovirus-Flt3 ligand injection.

    Cancer gene therapy·2007
    Same author

    Flt3 ligand bioactivity and pharmacology in neoplasia.

    Current drug targets. Immune, endocrine and metabolic disorders·2004
    Same journal

    Wavelet domain nonlinear filtering for evoked potential signal enhancement.

    Computers and biomedical research, an international journal·2001
    Same journal

    Time-frequency analysis of the RT and RR variability to stratify hypertrophic cardiomyopathy patients.

    Computers and biomedical research, an international journal·2001
    Same journal

    Controlled auxotonic twitch in papillary muscle: a new computer-based control approach.

    Computers and biomedical research, an international journal·2001
    Same journal

    Controlling for chance agreement in the validation of medical expert systems with no gold standard: PNEUMON-IA and RENOIR revisited.

    Computers and biomedical research, an international journal·2001
    Same journal

    Artificial neural networks compared to factor analysis for low-dimensional classification of high-dimensional body fat topography data of healthy and diabetic subjects.

    Computers and biomedical research, an international journal·2000
    Same journal

    On the parallelization of linkmap from the LINKAGE/FASTLINK package.

    Computers and biomedical research, an international journal·2000
    See all related articles

    A new FORTRAN program, MUDIFT, offers a distribution-free test for comparing growth curves, especially with varied or incomplete data. It found significantly slower tumor growth in treated mice compared to controls.

    Area of Science:

    • Biostatistics
    • Computational Biology
    • Pharmacology

    Background:

    • Comparing growth curves is crucial in biological and medical research.
    • Traditional methods often assume specific growth function forms, limiting applicability.
    • Handling diverse or incomplete longitudinal data presents analytical challenges.

    Purpose of the Study:

    • To introduce MUDIFT, an interactive FORTRAN program for multivariate distribution-free growth curve comparison.
    • To provide a statistical tool for analyzing complex growth patterns without assuming functional forms.
    • To assess the efficacy of a novel treatment by comparing tumor growth rates.

    Main Methods:

    • Development of MUDIFT, an interactive program utilizing a multivariate distribution-free significance test.

    Related Experiment Videos

  • Application of MUDIFT to analyze serial tumor volume data from mice.
  • Utilizing an asymptotically chi-squared test statistic for hypothesis testing.

    • Main Results:

    • The MUDIFT program successfully analyzed tumor growth data from treated and control mouse groups.
    • The analysis revealed a significant difference in tumor growth rates between the groups (chi-squared = 7.312, df = 2, p < 0.05).
    • Tumor growth was significantly slower in the group treated with liposome-incorporated muramyltripeptide phosphatidylethanolamine.

    Conclusions:

    • MUDIFT is a valuable tool for analyzing growth curves, particularly when data are heterogeneous or incomplete.
    • The study demonstrates the effectiveness of liposome-incorporated muramyltripeptide phosphatidylethanolamine in inhibiting tumor growth.
    • Distribution-free methods offer a robust alternative for growth curve analysis in complex biological systems.