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Updated: Jul 4, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
BRCA 1/2 mutations and risk of uterine cancer: a systematic review and meta-analysis
Faezeh Zakerinasab1, Qumars Behfar2, Reza Parsaee3
1Mashhad University of Medical Sciences, Mashhad, Iran.
Purpose:
In this study, we aim to investigate the association between BRCA1/2 mutation and uterine cancer incidence.
Material And Method:
We systematically searched three databases including PubMed, Scopus, and Google Scholar up to August 2023; and reviewed 23 cohorts and cross-sectional studies to explore the association between BRCA1/2 mutations and uterine cancer incidence.
Results:
This systematic review comprised a total of 21 cohort studies and 2 cross-sectional studies after the screening process. According to meta-analysis the prevalence of the BRCA1/2 gene in patients with uterine cancer was 0.02 (95%CI = [0.01,0.03], P < 0.01, I2 = 94.82%) CONCLUSIONS: Our meta-analysis investigates a 2% prevalence of BRCA1/2 mutation in patients with uterine cancer. Patients with BRCA1/2 mutations might be more conscious of uterine malignancies.
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