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A time window for rescuing dying retinal ganglion cells
Wenting You1,2,3, Kèvin Knoops4, Iris Boesten1
1University Eye Clinic Maastricht UMC+, Maastricht University Medical Center+, Maastricht, 6229 HX, The Netherlands.
Cell Communication and Signaling : CCS
|January 31, 2024
Summary
Retinal ganglion cells (RGCs) can recover from early-stage injury if the death stimulus is removed before key irreversible events occur. This identifies a critical window for rescuing RGCs and preventing vision loss in glaucoma.
Area of Science:
- Neuroscience
- Cell Biology
- Ophthalmology
Background:
- Glaucoma leads to vision loss through retinal ganglion cell (RGC) degeneration.
- Regulated cell death is typically irreversible once initiated.
- Previous studies showed PC12 cells can recover from cell death stimuli if removed promptly.
