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Candida epiglottitis in immunocompromised patients.

T J Walsh, W C Gray

    Chest
    |April 1, 1987
    PubMed
    Summary

    Candida epiglottitis is a rare fungal infection, often overlooked in immunocompromised patients with neoplastic disease. Early diagnosis and treatment with amphotericin B are crucial for managing this condition.

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    Area of Science:

    • Infectious Diseases
    • Mycology
    • Oncology

    Background:

    • Candida epiglottitis is an uncommon clinical presentation.
    • Neoplastic disease and granulocytopenia are significant risk factors.

    Observation:

    • Three cases of Candida epiglottitis in patients with neoplastic disease and granulocytopenia are presented.
    • Clinical manifestations included localized infection, Candida bronchopneumonia, and disseminated infection.

    Findings:

    • Candida epiglottitis can be under-diagnosed, particularly in immunocompromised individuals with refractory pharyngitis.
    • Intravenous amphotericin B is recommended for sustained granulocytopenia.
    • Endotracheal intubation is necessary if airway patency is compromised.

    Implications:

    • Increased clinical suspicion for Candida epiglottitis is warranted in at-risk populations.
    • Timely and appropriate treatment can improve patient outcomes.
    • This condition highlights the importance of considering fungal infections in immunocompromised hosts.

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