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Abstract:
Candida seldom has been reported to be a cause of epiglottitis. The clinical manifestations and management of three patients with Candida epiglottitis complicating their neoplastic disease are described. All patients were granulocytopenic. Candida epiglottitis occurred either as a localized infection, as a source of Candida bronchopneumonia, or as a manifestation of disseminated infection. Candida epiglottitis may be under-diagnosed and should be considered, especially in immunocompromised patients with symptoms of refractory pharyngitis. Treatment of Candida epiglottitis with intravenous amphotericin B is warranted in patients with sustained granulocytopenia. Prompt endotracheal intubation is indicated if the airway patency cannot be maintained.
Insights
Candida epiglottitis is a rare fungal infection, often overlooked in immunocompromised patients with neoplastic disease. Early diagnosis and treatment with amphotericin B are crucial for managing this condition.
Area of Science:
- Infectious Diseases
- Mycology
- Oncology
Background:
- Candida epiglottitis is an uncommon clinical presentation.
- Neoplastic disease and granulocytopenia are significant risk factors.
Observation:
- Three cases of Candida epiglottitis in patients with neoplastic disease and granulocytopenia are presented.
- Clinical manifestations included localized infection, Candida bronchopneumonia, and disseminated infection.
Findings:
- Candida epiglottitis can be under-diagnosed, particularly in immunocompromised individuals with refractory pharyngitis.
- Intravenous amphotericin B is recommended for sustained granulocytopenia.
- Endotracheal intubation is necessary if airway patency is compromised.
Implications:
- Increased clinical suspicion for Candida epiglottitis is warranted in at-risk populations.
- Timely and appropriate treatment can improve patient outcomes.
- This condition highlights the importance of considering fungal infections in immunocompromised hosts.