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Patients' preferences for systemic treatment of atopic dermatitis: safety and efficacy count the most

Marthe-Lisa Schaarschmidt1, Daniel Kromer2, Phoebe Wellmann3

  • 1Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.

The Journal of Dermatological Treatment
|February 1, 2024
PubMed
Abstract

Insights

Patients with atopic dermatitis prioritize treatment safety and symptom control, with preferences influenced by individual factors. Shared decision-making in treatment is crucial for effective atopic dermatitis management.

Area of Science:

  • Dermatology
  • Pharmacoeconomics
  • Patient-Reported Outcomes

Background:

  • Biologics and janus kinase (JAK) inhibitors have transformed atopic dermatitis (AD) treatment.
  • Understanding patient preferences is key for optimizing systemic therapy selection in AD.

Purpose of the Study:

  • To investigate patient preferences for attributes of approved systemic atopic dermatitis treatments.
  • To identify factors influencing these preferences in German patients with AD.

Main Methods:

  • An online discrete choice experiment was utilized.
  • Patients evaluated outcome attributes (skin clearance, itch relief, side effects) and process attributes (administration, lab tests).

Main Results:

  • Side effects (31.2%), skin clearance (24.2%), and itch improvement (16.0%) were the most important attributes.
  • Application method (14.4%), time to itch relief (7.4%), and lab tests (6.8%) were less critical.
  • Patient sex, age, comorbidities, current therapy, and quality of life significantly influenced preferences.

Conclusions:

  • Safety and symptom control are paramount for patients with atopic dermatitis.
  • Individual patient characteristics necessitate personalized treatment counseling.
  • Integrating patient preferences into shared decision-making is fundamental for AD management.
Keywords:
Atopic dermatitisbiologicsconjoint analysisdiscrete choice experimentjanus kinase inhibitorspreferences

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