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Triple-Negative or Close-to-Triple-Negative Breast Cancer Presenting as a Thick-Walled Cystic Lesion
Li Gan1, Junyuan Xie1, Kaiqiang Li1
1Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
The American Surgeon
|February 1, 2024
Summary
Invasive ductal carcinoma (IDC) can present as a thick-walled breast cyst, often indicating a highly aggressive, triple-negative breast cancer. Early identification and appropriate management of these malignant cystic lesions are crucial for patient outcomes.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Invasive ductal carcinoma (IDC) rarely presents as a thick-walled breast cyst.
- The clinical and pathological features of this presentation are not well-documented.
Purpose of the Study:
- To describe the clinical, imaging, and pathological characteristics of invasive ductal carcinoma presenting as a thick-walled breast cyst.
- To highlight the aggressive nature and potential triple-negative status of such tumors.
Main Methods:
- Case series involving three female patients with breast malignancy.
- Diagnostic imaging included mammography, ultrasonography, and magnetic resonance imaging (MRI).
- Pathological confirmation of grade III IDC and receptor status (ER, PR, HER2).
Main Results:
- All patients presented with a palpable breast lump.
- Imaging revealed thick-walled cystic masses with characteristic rim enhancement on MRI.
- All cases were confirmed as grade III IDC, with most being triple-negative breast cancer.
Conclusions:
- Breast cancer presenting as a thick-walled cystic mass can be highly aggressive, including triple-negative IDC.
- Timely identification of potentially malignant cystic lesions is essential for appropriate breast cancer management.
- Multimodality imaging plays a key role in characterizing these lesions.
