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Non-Epstein-Barr Virus Sinonasal Undifferentiated Carcinoma Presenting as Diplopia and Rhinorrhea
Syeda Q Kaifee1,2, Yawar Haq3, Birkaran Sadhar4
1Internal Medicine and Ophthalmology, Rochester Regional Hospital, Rochester, USA.
Cureus
|February 1, 2024
Summary
Sinonasal undifferentiated carcinoma (SNUC) is a rare cancer. This case report details a non-EBV SNUC diagnosis in a patient with atypical symptoms and a history of bladder cancer.
Area of Science:
- Oncology
- Pathology
Background:
- Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy of the nasal cavity and paranasal sinuses.
- Its low incidence and unclear etiology, including the role of Epstein-Barr virus (EBV), present research challenges.
Observation:
- A patient presented with chronic rhinorrhea and ophthalmologic symptoms (flashes, floaters, diplopia).
- The patient had a history of bladder cancer and negative serological testing for EBV.
Findings:
- The patient was diagnosed with non-EBV sinonasal undifferentiated carcinoma.
- Diagnostic modalities, management, and outcome were analyzed in this rare case.
Implications:
- This case contributes to understanding SNUC, particularly non-EBV variants.
- Highlights the importance of considering atypical presentations and comorbidities in SNUC diagnosis.
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