LEFT VENTRICULAR NONCOMPACTION CARDIOMYOPATHY: A SCOPING REVIEW.

Area of Science:

• Cardiology
• Genetics
• Medical Imaging

Background:

• Left Ventricular Noncompaction (LVNC) cardiomyopathy, first described in 1926, has seen increased reporting due to advanced medical imaging.
• Classified variably by major cardiac societies, LVNC presents diverse genetic profiles, phenotypes, and clinical manifestations.
• Its complex nature suggests it may be a variant of other cardiomyopathies.

Purpose of the Study:

• To review current knowledge on Left Ventricular Noncompaction (LVNC) cardiomyopathy.
• To consolidate information on the diagnosis, presentation, and management of LVNC.
• To highlight the genetic underpinnings and implications for family screening.

Main Methods:

• Literature review of Left Ventricular Noncompaction (LVNC) cardiomyopathy.
• Analysis of diagnostic modalities, including echocardiography and advanced cardiac imaging.
• Synthesis of clinical presentations, management strategies, and genetic associations.

Main Results:

• Increased reporting of LVNC cases attributed to improved echocardiography and cardiac imaging techniques.
• Clinical presentations range from asymptomatic to severe outcomes like arrhythmias, heart failure, and sudden death.
• Genetic associations are significant, underscoring the importance of screening relatives.

Conclusions:

• Left Ventricular Noncompaction (LVNC) is a complex cardiomyopathy with increasing recognition.
• Early diagnosis through imaging and genetic evaluation is crucial for effective management.
• Family screening is essential due to the genetic basis of LVNC.