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Updated: Jul 4, 2025
Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
Sleeve gastrectomy and one-year outcomes: Impact on cardiovascular, renal and metabolic parameters
Maria Irene Bellini1, Lidia Castagneto Gissey1, Denise V Nemeth2
1Department of Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Background:
Cardiovascular and renal diseases represent a major determinant for the morbidity and mortality associated with obesity and type 2 diabetes mellitus (T2DM). Bariatric surgery is considered one of the few treatments with the potential to reverse cardiovascular, renal and metabolic disease.
Methods:
Prospective study of patients undergoing sleeve gastrectomy collecting pre- and post-surgery creatinine, eGFR, glucose, insulin, total, LDL/HDL cholesterol, triglycerides, parathyroid hormone, vitamin D3, C- Reactive Protein (CRP), blood count, weight, body mass index (BMI), bilateral carotid intima media thickness (IMT), flow-mediated dilation (FMD) and epicardial adipose tissue (EAT). Measurements were compared at 1 year follow up.
Results:
24 patients were included in the study. Cardiovascular parameters, as HDL-cholesterol (p = 0.002), IMT (p = 0.003), EAT (p < 0.001) and FMD (p = 0.001) showed significant improvement after surgery. Secondary renal outcomes including Vitamin D3 (p < 0.0001), Calcium (p = 0.006), RBCs (p = 0.007), HCO3- (p = 0.05) also ameliorated as well as BMI (p < 0.001).
Conclusions:
Sleeve gastrectomy has a positive impact on cardiovascular, renal, and metabolic parameters in patients with morbid obesity, suggesting it may halt the progression of these diseases even in the preclinical stage. Further research is needed to explore the long-term effects underlying these improvements.
Insights
Sleeve gastrectomy significantly improves cardiovascular, renal, and metabolic health in patients with morbid obesity. This bariatric surgery shows potential to reverse disease progression, even in early stages.
Area of Science:
- Metabolic and Bariatric Surgery
- Cardiovascular Medicine
- Nephrology
Background:
- Obesity and type 2 diabetes mellitus (T2DM) are major causes of cardiovascular and renal disease morbidity and mortality.
- Bariatric surgery offers a potential treatment to reverse these associated conditions.
Purpose of the Study:
- To evaluate the impact of sleeve gastrectomy on cardiovascular, renal, and metabolic parameters in patients with morbid obesity.
- To assess changes in key health indicators one year after surgery.
Main Methods:
- Prospective study involving 24 patients undergoing sleeve gastrectomy.
- Collection and comparison of pre- and post-surgery measurements including BMI, lipids, glucose, renal function markers, inflammatory markers, and cardiovascular indicators (IMT, FMD, EAT).
Main Results:
- Significant improvements observed in HDL-cholesterol, carotid intima media thickness (IMT), epicardial adipose tissue (EAT), and flow-mediated dilation (FMD) (p < 0.003).
- Amelioration of secondary renal outcomes including Vitamin D3, Calcium, RBCs, and HCO3- (p < 0.05).
- Significant reduction in Body Mass Index (BMI) (p < 0.001).
Conclusions:
- Sleeve gastrectomy positively impacts cardiovascular, renal, and metabolic parameters in patients with morbid obesity.
- The findings suggest bariatric surgery may halt disease progression, potentially even in preclinical stages.
- Further research is warranted to understand the long-term effects of these improvements.
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