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Published on: September 17, 2021
Crosstalk between MicroRNAs and Oxidative Stress in Coeliac Disease
Filippo Pelizzaro1,2, Romilda Cardin1, Giulia Sarasini1
1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy.
Abstract:
MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in regulating gene expression. Many studies, mostly conducted on pediatric patients, suggested that oxidative stress and several miRNAs may play an important role in coeliac disease (CeD) pathogenesis. However, the interplay between oxidative stress and miRNA regulatory functions in CeD remains to be clarified. In this review, we aimed to perform a literature review on the role of miRNAs and oxidative stress in adult CeD patients and to analyze their potential interactions. In this direction, we also reported the preliminary results of a pilot study we recently performed.
Insights
Oxidative stress and microRNAs (miRNAs) are implicated in celiac disease (CeD). This review clarifies their roles and interactions in adults, presenting new pilot study findings on miRNA regulation in CeD pathogenesis.
Area of Science:
- Molecular Biology
- Gastroenterology
- Immunology
Background:
- MicroRNAs (miRNAs) are small, non-coding RNAs regulating gene expression.
- Oxidative stress and specific miRNAs are suggested contributors to celiac disease (CeD) pathogenesis, primarily in pediatric studies.
- The interaction between oxidative stress and miRNA functions in adult CeD remains unclear.
Purpose of the Study:
- To review the role of miRNAs and oxidative stress in adult celiac disease.
- To analyze the potential interactions between oxidative stress and miRNA regulatory functions in adult CeD.
- To present preliminary findings from a recent pilot study.
Main Methods:
- Literature review focusing on adult celiac disease patients.
- Analysis of existing studies on miRNAs and oxidative stress in CeD.
- Inclusion of preliminary data from a novel pilot study.
Main Results:
- Synthesis of current knowledge on miRNA and oxidative stress involvement in adult CeD.
- Identification of potential interactive pathways.
- Presentation of initial pilot study results (details to be elaborated).
Conclusions:
- Oxidative stress and miRNAs are significant factors in adult celiac disease.
- Further research is needed to fully elucidate their complex interplay and therapeutic potential.
- The pilot study provides a basis for future investigations into miRNA-targeted interventions for adult CeD.
