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[Can beta-receptor blockers trigger coronary spasm?].

G Cieslinski, R Hopf, G Kober

    Deutsche Medizinische Wochenschrift (1946)
    |April 10, 1987
    PubMed
    Summary
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    Beta-blockers can worsen coronary blood flow, potentially causing heart issues. Switching to calcium antagonists may improve symptoms and reduce ischemia in affected patients.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Beta-blockers are common treatments for hypertension and coronary heart disease.
    • They typically increase vascular resistance without noticeable symptoms.

    Observation:

    • Three patients showed decreased myocardial blood flow while on beta-blockers.
    • These patients experienced improved exercise ECG and symptom relief after switching to calcium antagonists.

    Findings:

    • Beta-blockers may induce coronary spasms, negatively impacting myocardial blood flow.
    • This effect is particularly relevant in patients with existing coronary artery disease.

    Implications:

    • Clinicians should consider beta-blocker-induced coronary spasms during therapy monitoring.

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  • Alternative treatments like calcium antagonists may be beneficial for managing ischemia in these cases.