Related Experiment Video
Updated: Jul 4, 2025
10:45
Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
Published on: May 25, 2017
14.3K
Alcohol-associated liver disease
The Journal of Clinical Investigation
|February 1, 2024
Summary
Alcohol-associated liver disease (ALD) research is advancing, but its causes and treatments remain unclear. This review explores multiomics and other novel approaches to understand ALD pathogenesis and identify new therapeutic targets.
Area of Science:
- Hepatology
- Gastroenterology
- Translational Medicine
Background:
- Alcohol-associated liver disease (ALD) is a leading global cause of chronic liver disease.
- ALD encompasses a range of conditions, from simple steatosis to cirrhosis and liver cancer.
- Despite progress, ALD pathogenesis is not fully understood, and no FDA-approved treatments exist.
Purpose of the Study:
- To review recent advancements in understanding ALD pathogenesis.
- To explore novel therapeutic targets for ALD.
- To discuss the translational potential of cutting-edge research in ALD treatment.
Main Methods:
- Review of multiomics studies.
- Analysis of preclinical ALD models.
- Examination of emerging research approaches.
Main Results:
- New insights into ALD pathogenesis are emerging from multiomics and advanced research.
- Potential therapeutic targets are being identified.
- The heterogeneity of ALD and its link to metabolic dysfunction are highlighted.
Conclusions:
- Cutting-edge research, including multiomics, offers promising avenues for understanding and treating ALD.
- Translational research is crucial for developing effective therapies for alcohol-associated liver disease.
- Further investigation into ALD heterogeneity and its interplay with metabolic factors is warranted.
Related Concept Videos
01:26Diseases of the Liver and Gallbladder
540
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
540
01:17Gastritis-II: Pathophysiology
327
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
327
01:12Acid Halides to Esters: Alcoholysis
2.8K
Alcoholysis is a nucleophilic acyl substitution reaction in which an alcohol functions as a nucleophile. Acid halides react with alcohol to produce esters. The mechanism proceeds in three steps:
2.8K
01:19Aldehydes and Ketones with Alcohols: Hemiacetal Formation
6.2K
Similar to water, alcohols can add to the carbonyl carbon of the aldehydes and ketones. The addition of one molecule of alcohol to the carbonyl compound forms the hemiacetal or half acetal. As depicted below, in a hemiacetal, the carbon is directly linked to an OH and OR group.
6.2K
01:26Alzheimer's Disease: Overview
487
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
487
01:19Acid Halides to Alcohols: LiAlH4 Reduction
2.8K
Acid halides are reduced to alcohols in the presence of a strong reducing agent like lithium aluminum hydride.
The mechanism proceeds in three steps. First, the nucleophilic hydride ion attacks the carbonyl carbon of the acid halide to form a tetrahedral intermediate. Next, the carbonyl group is re-formed, and the halide ion departs as a leaving group, generating an aldehyde. A second nucleophilic attack by the hydride yields an alkoxide ion, which, upon protonation, gives a primary alcohol as...
The mechanism proceeds in three steps. First, the nucleophilic hydride ion attacks the carbonyl carbon of the acid halide to form a tetrahedral intermediate. Next, the carbonyl group is re-formed, and the halide ion departs as a leaving group, generating an aldehyde. A second nucleophilic attack by the hydride yields an alkoxide ion, which, upon protonation, gives a primary alcohol as...
2.8K