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Updated: Jul 4, 2025
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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Emerging biologic therapies for systemic lupus erythematosus
Hiroshi Kato1, J Michelle Kahlenberg
1University of Michigan Lupus Program, Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Current Opinion in Rheumatology
|February 1, 2024
Summary
New therapies for systemic lupus erythematosus (SLE) offer hope, expanding treatment options beyond belimumab and anifrolumab. While some candidates face challenges, targeted treatments for SLE are advancing.
Area of Science:
- Immunology
- Rheumatology
- Pharmacology
Background:
- Systemic lupus erythematosus (SLE) treatment options are expanding with recent approvals.
- Many SLE patients remain refractory to existing therapies and experience drug toxicities.
Approach:
- This review discusses approved and emerging target-specific therapeutics for SLE.
- It analyzes recent clinical trial findings for novel SLE treatments.
Key Points:
- Anifrolumab and belimumab are now FDA-approved for SLE and lupus nephritis (LN).
- Phase II trials show promise for obinutuzumab (LN), deucravacitinib (SLE), and litifilimab (SLE/CLE).
- Ustekinumab and baricitinib showed efficacy in Phase II but not Phase III trials.
Conclusions:
- Despite Phase III trial failures for some candidates, the pipeline for targeted SLE therapies continues to grow.
- These advancements offer hope for improved outcomes in patients with refractory SLE.
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