Related Experiment Video
Updated: Jul 4, 2025
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
Published on: April 14, 2016
[Metabolic bone diseases : what's new in 2023]
Serge Ferrari1, Andrea Trombetti1, Anne-Cecile Debrach1
1Service des maladies osseuses, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
The sequential effects of romosozumab and denosumab in osteoporosis are shown in real-life, while the mechanisms of post-denosumab rebound are reviewed extensively. A network meta-analysis confirms the superiority of anabolics vs anti-resorptives on fracture reduction, while the latter shown a reduction of mortality in a large population-based study. Fracture risk prediction by FRAXPlus is improved. New meta-analyses confirm the benefits of Vitamin D on fractures and falls. Finally, multiples trials with new molecules for the treatment of rare bone diseases, including osteogenesis imperfecta, fibrous dysplasia and hypoparathyroidism, shown promising results.
Insights
This review explores osteoporosis treatments, comparing anabolic and anti-resorptive drugs for fracture reduction. It also highlights advancements in predicting fracture risk and treating rare bone diseases.
Area of Science:
- Endocrinology and Bone Metabolism
- Pharmacology of Bone Therapeutics
- Clinical Osteoporosis Management
Context:
- Real-world data on sequential romosozumab and denosumab therapy for osteoporosis.
- Extensive review of the mechanisms underlying post-denosumab rebound.
- Evaluation of current fracture risk prediction tools and emerging therapeutic strategies.
Purpose:
- To synthesize current evidence on osteoporosis treatment efficacy and safety.
- To elucidate the pathophysiology of bone density changes after antiresorptive therapy cessation.
- To assess the comparative effectiveness of different drug classes and novel agents.
Summary:
- Network meta-analysis confirms anabolic agents outperform anti-resorptives in reducing fractures.
- Large-scale study indicates anti-resorptives reduce mortality.
- FRAXPlus improves fracture risk prediction; Vitamin D benefits confirmed for fractures and falls.
- Promising results from trials of new molecules for rare bone diseases like osteogenesis imperfecta.
Impact:
- Informs clinical decision-making for osteoporosis management strategies.
- Provides insights into managing treatment transitions and potential bone loss.
- Advances understanding and treatment of complex bone disorders.
- Enhances patient outcomes through improved fracture prevention and disease management.
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