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Recent advances in the prevention of respiratory syncytial virus in pediatrics

Madeline A Lipp1,2, Kerry M Empey1,2,3

  • 1Center for Clinical Pharmaceutical Sciences.

Current Opinion in Pediatrics
|February 1, 2024
PubMed

Insights

New therapies for respiratory syncytial virus (RSV) are now available for infants and children. Ongoing research and careful monitoring are crucial for ensuring the long-term safety of these vital RSV prevention strategies.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Immunology

Background:

  • Respiratory syncytial virus (RSV) is a primary cause of pediatric hospitalization in the U.S.
  • Effective prevention strategies are critical for reducing the burden of RSV in children.
  • Recent advancements have led to new FDA-approved agents for RSV prevention.

Approach:

  • This review highlights recent developments in pediatric RSV prevention.
  • It examines novel preventive therapies approved in 2023 and those in the development pipeline.
  • Safety considerations for clinical trials of new RSV interventions are discussed.

Key Points:

  • Two new preventive therapies, a maternal vaccine (Abrysvo) and a monoclonal antibody (mAb, Beyfortus), were FDA-approved in 2023.
  • Both Abrysvo and Beyfortus demonstrated efficacy in reducing medically attended lower respiratory tract infections in infants and children.
  • Clinical trials are exploring diverse immunization methods for direct infant and child protection against RSV.

Conclusions:

  • RSV prevention is increasingly accessible for pediatric populations.
  • Careful evaluation of risks associated with new and emerging prevention strategies is essential.
  • Rigorous clinical trials and postmarketing surveillance are paramount for ensuring the long-term safety of novel RSV prevention methods.
Abstract

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