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Prognostic factors of primary intrascrotal rhabdomyosarcoma in children: a population-based study
Xianzhong Qi1, Dongsheng Zhu2, Qianwei Xiong3
1Department of Pathology, First People's Hospital of Linping District, Hangzhou, 311199, Zhejiang, China.
Insights
This study identified SEER stage and surgery as key prognostic factors for pediatric intrascrotal rhabdomyosarcoma (RMS). These findings offer crucial epidemiological data to guide clinical treatment decisions for this rare cancer.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Epidemiology
Background:
- Intrascrotal rhabdomyosarcoma (RMS) is a rare and aggressive pediatric malignancy.
- Understanding prognostic factors is crucial for effective clinical management.
Purpose of the Study:
- To identify prognostic factors influencing overall survival (OS) in children with intrascrotal RMS.
- To develop a predictive model for patient outcomes.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database for patient data (2000-2018).
- Employed log-rank tests for survival curve comparisons.
- Developed a multivariate Cox proportional hazards model and a nomogram for OS prediction.
Main Results:
- Identified 102 pediatric cases of intrascrotal RMS.
- Overall survival rates were 90.6% at 3 years and 87.2% at 5 years.
- SEER stage and surgical intervention were significant independent predictors of OS; chemotherapy and lymph node removal were not.
Conclusions:
- SEER stage and surgical status are the most critical indicators for OS in pediatric intrascrotal RMS.
- Findings provide essential epidemiological insights for guiding clinical therapy.
Purpose:
Primary intrascrotal rhabdomyosarcoma (RMS) is a rare and aggressive tumor. The purpose of this study was to investigate the prognostic factors of intrascrotal RMS in children.
Methods:
All pediatric patients with intrascrotal RMS diagnosed between 2000 and 2018 were identified using the Surveillance, Epidemiology, and End Results (SEER) database. To compare survival curves, the log-rank test was employed. A multivariate Cox proportional hazards model was developed to investigate the effect of each factor on overall survival (OS). A nomogram was created using the outcomes of the Cox regression model.
Results:
A total of 102 pediatric patients with intrascrotal RMS were identified. Overall survival rates for all patients were 90.6% at 3-year and 87.2% at 5-year, respectively. Survival rates differed significantly by SEER stage and surgery; however, chemotherapy and removal of lymph nodes showed no significant difference. The outcome of Cox proportional hazard regression revealed that SEER stage and surgery were important independent predictors in this model. Furthermore, we developed a nomogram for predicting OS in pediatric intrascrotal RMS based on the Cox regression model. The risk of death increased with stage in patients. Additionally, patients who underwent surgery had a lower mortality risk than those who did not.
Conclusions:
Our findings show that SEER stage and surgery are the most important indicators of OS in children with intrascrotal RMS, providing critical epidemiological information for clinical therapy.
