Multilayer microparticles for programmed sequential release of phenolic compounds from Eugenia stipitata: Stability...

Area of Science:

• Food Science and Technology
• Materials Science
• Biochemistry

Background:

• Phenolic compounds (PCs) are vital antioxidants but suffer from poor stability and bioavailability.
• Developing effective delivery systems is crucial for maximizing the health benefits of PCs.

Purpose of the Study:

• To create and characterize a multilayer microparticle co-delivery system for sequential PC release.
• To evaluate the impact of different encapsulation methods (spray drying and drying-chilling spray) and wall materials on PC stability and bioavailability.

Main Methods:

• Co-delivery system development using multilayer microparticles.
• Encapsulation via spray drying (SD) and drying-chilling spray (SDC).
• Characterization using techniques like NMR, FTIR, DXR, DSC, ORAC, ABTS, and in vitro digestion.

Main Results:

• Spray drying (SD) resulted in significantly higher phenolic retention efficiency (PRE%) compared to SDC, attributed to PC formation from cará-roxo flour.
• Spectroscopic and thermal analyses confirmed the formation of an advanced co-delivery system.
• SDC particles exhibited crystalline regions and thermal stability around 47°C.
• All systems demonstrated effective PC release during the intestinal phase and retained significant anti-radical capacity (up to 23.66 µmol TE g⁻¹).

Conclusions:

• The developed multilayer microparticle system effectively co-delivers phenolic compounds.
• Spray drying is a superior method for encapsulating PCs, leading to higher retention and bioavailability.
• This advanced delivery system holds promise for enhancing the stability and efficacy of phenolic compounds in functional foods and nutraceuticals.