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Updated: Jul 4, 2025
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Published on: August 12, 2020
Gut Microbiota and Neonatal Acute Kidney Injury
Kun Yang1,2,3, Hongxia He1,2,3, Wenbin Dong1,2,3
1Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Objective:
To characterize the relationship between gut microbiota and neonatal acute kidney injury biomarkers based on the gut-kidney axis.
Study Design:
The Pubmed database was primarily searched to include relevant literature on gut microbiota and neonatal acute kidney injury biomarkers, which was subsequently organized and analyzed and a manuscript was written.
Results:
Gut microbiota was associated with neonatal acute kidney injury biomarkers. These biomarkers included TIMP-2, IGFBP-7, VEGF, calbindin, GST, B2MG, ghrelin, and clusterin.
Conclusion:
The gut microbiota is strongly associated with neonatal acute kidney injury biomarkers, and controlling the gut microbiota may be a potential target for ameliorating neonatal acute kidney injury.
Key Points:
· There is a bidirectional association between gut microbiota and AKI.. · Gut microbiota is closely associated with biomarkers of nAKI.. · Manipulation of gut microbiota may improve nAKI..
