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Related Experiment Video

Updated: Jun 28, 2026

Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model

Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model

Published on: September 14, 2009

Comparison Among Ultra-Thin Coronary Stents: A Network Meta-Analysis.

Giorgio Marengo¹, Francesco Bruno¹, Luca Scudeler¹

¹Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, University of Turin, Italy.

The American Journal of Cardiology

|February 1, 2024

Summary

Ultrathin drug-eluting stents (DES) show comparable target lesion failure (TLF) to thicker-strut DES. Among ultrathin options, Orsiro demonstrated the highest probability for best performance in TLF and target lesion revascularization (TLR).

Keywords:

network meta-analysis percutaneous coronary intervention ultrathin drug-eluting stents

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Published on: November 19, 2020

Area of Science:

Cardiology
Medical Devices
Interventional Cardiology

Background:

Ultrathin-strut drug-eluting stents (DES) may offer improved outcomes compared to thicker-strut DES.
Limited comparative data exists among different ultrathin DES devices.

Purpose of the Study:

To compare the efficacy and safety of various ultrathin DES against each other and against thicker-strut DES.
To evaluate target lesion failure (TLF) and other key clinical outcomes at 1-year follow-up.

Main Methods:

Network meta-analysis of randomized controlled trials comparing ultrathin (<70 µm struts) and thicker-strut DES in an all-comers population.
Primary endpoint: Target Lesion Failure (TLF) at 1-year.
Secondary endpoints: Overall mortality, myocardial infarction, target lesion revascularization (TLR), and stent thrombosis.

Main Results:

Nine studies with 20,081 patients were included; 9,509 received ultrathin DES (Orsiro, MiStent, Supraflex).
No significant differences in TLF were observed among ultrathin DES at 1-year.
Orsiro showed a similar TLF risk to Supraflex and the highest probability for best performance in TLF, myocardial infarction, and TLR.

Conclusions:

Ultrathin DES demonstrate comparable TLF risk to thicker-strut DES.
Orsiro exhibited the highest likelihood of superior performance regarding TLF and TLR compared to other ultrathin DES and thicker-strut devices.