Related Experiment Video

Updated: Jul 13, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Right atrial thrombosis in two premature infants: successful treatment with urokinase and heparin

G Pongiglione, M Marasini, D Ribaldone

    European Heart Journal
    |December 1, 1986
    PubMed

    Insights

    This study shows that heparin and urokinase effectively treat intra-atrial thrombosis in premature infants. Echocardiography helps guide this fibrinolytic therapy as a potential alternative to surgery.

    Area of Science:

    • Neonatal Medicine
    • Cardiovascular Medicine
    • Pediatric Thrombosis

    Background:

    • Vascular thrombosis, particularly intracardiac thrombosis, is a serious concern in premature infants.
    • Surgical intervention has been the primary treatment for surviving cases of intracardiac thrombosis in preterm neonates.

    Observation:

    • Two premature infants presented with intra-atrial thrombosis, diagnosed via cross-sectional echocardiography.
    • These infants were successfully treated with prolonged courses of heparin and urokinase.

    Findings:

    • Treatment required higher doses and longer durations of urokinase compared to older patients to achieve thrombolysis.
    • Cross-sectional echocardiography proved valuable for monitoring and adjusting fibrinolytic therapy.

    Implications:

    • Fibrinolytic therapy, using agents like urokinase, presents a viable, less invasive alternative to surgery for right atrial thrombosis in premature infants.
    • This approach, guided by echocardiography, may improve outcomes for neonates with this condition.

    More Related Videos

    Prehospital Thrombolysis: A Manual from Berlin05:52

    Prehospital Thrombolysis: A Manual from Berlin

    Published on: November 26, 2013

    Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter08:00

    Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter

    Published on: June 15, 2015

    Related Concept Videos

    Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

    Anticoagulant Drugs: Low-Molecular-Weight Heparins

    Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
    Venous Thrombosis III: Interprofessional Care01:29

    Venous Thrombosis III: Interprofessional Care

    Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
    Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

    Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

    Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...