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Updated: Jul 4, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
Published on: December 1, 2023
The Current and Future Roles of Precision Oncology in Advanced Breast Cancer
Heather Jacene1, Eric Dietsche2, Jennifer Specht3
1Imaging/Radiology, Dana-Farber/Brigham Cancer Center, Boston, Massachusetts; hjacene@bwh.harvard.edu.
Abstract:
Breast cancer is a common but heterogeneous disease characterized by several biologic features, including tumor grade, hormone receptor status, human epidermal growth factor receptor 2 status, and gene expression assays. These biologic and genomic features drive treatment decisions. In the advanced disease setting, inter- and intrapatient tumor heterogeneity is increasingly recognized as a challenge for optimizing treatment. Recent evidence and the recent approval of novel radiopharmaceuticals have increased recognition and acceptance of the potential of molecular imaging as a biomarker to impact and guide management decisions for advanced breast cancer.
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