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Related Experiment Video

Updated: Jul 4, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

7.6K

Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography.

Silvia Feu-Basilio1, Peter M Maloca2,3,4, Pascal Hasler2

  • 1Hospital Clínic de Barcelona, University of Barcelona, Carrer de Sabino Arana, 1, 08028, Barcelona, Spain.

Scientific Reports
|February 1, 2024
PubMed
Summary

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This study presents the first 3D retinal vessel volume (VV) data from optical coherence tomography angiography (OCTA) in healthy individuals. Axial length significantly impacts VV, offering new insights into normal retinal vascular anatomy.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Optical coherence tomography angiography (OCTA) is a key imaging modality for retinal vasculature.
  • Quantification of 3D retinal vessel parameters like vessel volume (VV) is crucial but lacks representative data.
  • No published studies provide volume-rendered VV data from OCTA.

Purpose of the Study:

  • To establish normative 3D OCTA-derived vessel volume (VV) data in healthy subjects.
  • To investigate the influence of demographic and ocular factors on retinal VV.
  • To provide a reference for future research on retinal vascular anatomy.

Main Methods:

  • 3x3 mm macular cubes from 203 eyes of 107 healthy volunteers were analyzed using OCTA.
  • Volume-rendering techniques were employed to measure 3D retinal vessel volume (VV).

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Related Experiment Videos

Last Updated: Jul 4, 2025

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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
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Doppler Optical Coherence Tomography of Retinal Circulation
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  • Generalized linear models (GLM) assessed the impact of age, gender, visual acuity, spherical equivalent, and axial length on VV.

    • Main Results:

    • The overall mean 3D vessel volume (VV) was 0.23 ± 0.05 mm³.
    • Age and axial length showed a negative correlation with VV.
    • Axial length demonstrated the most significant influence on VV, while gender and eye laterality showed no significant association.

    Conclusions:

    • This study provides the first normative 3D OCTA-derived vessel volume (VV) data in a large cohort of healthy individuals.
    • Axial length is a primary determinant of normal retinal VV.
    • These findings establish a valuable reference for characterizing retinal vascular anatomy and potential deviations in disease states.