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Cells with annular nucleus in haemopathic patients
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1985
Summary
Cells with annular nucleus (CAN) were found in various anemias and leukemias. In chronic myeloid leukemia (CML), CAN in peripheral blood may originate from the spleen, suggesting impaired segmentation.
Area of Science:
- Hematology
- Cell Biology
Background:
- Cells with annular nucleus (CAN) are an unusual morphological finding.
- Their presence has been noted in various hematological conditions.
Purpose of the Study:
- To investigate the occurrence and characteristics of CAN in different hematological disorders.
- To explore the potential origin and implications of CAN in chronic myeloid leukemia (CML).
Main Methods:
- Morphological examination of bone marrow and peripheral blood smears from patients.
- Analysis of CAN frequency in relation to splenectomy and disease status in CML.
- Agar culture of peripheral blood cells to assess colony-forming cells (CFC) potential.
Main Results:
- CAN were observed in acute myeloid leukemia (AML), sideroblastic anemia (SA), megaloblastic anemia (MA), and particularly in chronic myeloid leukemia (CML).
- In CML, CAN were more prevalent in peripheral blood (16/31) than bone marrow (7/31).
- Reduced CAN in a splenectomized CML patient and higher peripheral blood counts suggest splenic origin for CML peripheral blood CAN. CAN were identified as neutrophilic, eosinophilic, or monocytic myelocytes, with some exhibiting morphocytochemical anomalies and impaired segmentation.
Conclusions:
- CAN are associated with several hematological conditions, notably CML.
- Peripheral blood CAN in CML may originate from the spleen, indicating a potential splenic role in their development.
- Further research into CAN may offer insights into myeloid cell differentiation and nuclear segmentation defects.