Related Experiment Video

Updated: Jul 4, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.6K

Cancer Pathways Targeted by Berberine: Role of microRNAs

Mansoor Ali1, Deepali Mishra1, Rana Pratap Singh1,2,3

  • 1Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

Current Medicinal Chemistry
|February 2, 2024
PubMed

Insights

Berberine, a natural compound, combats cancer by regulating microRNAs (miRNAs). This review explores how berberine influences cancer cell behavior and progression through miRNA modulation, offering new therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer is a complex disease driven by genetic and epigenetic changes, often rendering conventional therapies ineffective.
  • MicroRNA (miRNA) dysregulation is a key factor in cancer development, progression, and metastasis.
  • miRNAs hold potential as diagnostic, prognostic, and therapeutic targets in oncology.

Purpose of the Study:

  • To review the role of berberine in cancer treatment.
  • To elucidate how berberine regulates microRNAs (miRNAs) in cancer cells.
  • To explore the impact of berberine-mediated miRNA changes on cancer-related transcripts and proteins.

Main Methods:

  • Literature review of studies on berberine, miRNAs, and cancer.
  • Analysis of research detailing berberine's effects on cancer cell proliferation, metastasis, and apoptosis.
  • Examination of studies investigating berberine's influence on oncogenic and tumor suppressor miRNAs.

Main Results:

  • Berberine exhibits anticancer activities, including inhibition of proliferation, migration, invasion, and angiogenesis.
  • Berberine modulates the expression of numerous oncogenic and tumor suppressor miRNAs.
  • Berberine-mediated miRNA regulation alters transcript and protein profiles, impacting cancer progression.

Conclusions:

  • Berberine shows significant potential as an anticancer agent through its ability to regulate miRNAs.
  • Understanding berberine-induced miRNA alterations provides insights into molecular pathways crucial for combating cancer.
  • Berberine's miRNA-targeting mechanisms offer a promising avenue for novel cancer therapies.
Keywords:
Cancerberberinebiomarker.cellular pathwaysmiRNAtranscriptome

More Related Videos

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

17.6K
An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.4K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.6K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K