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A 48-Year-Old Man With a Hip Fracture and Skin Rash: A Case Report.

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|February 2, 2024
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Summary
This summary is machine-generated.

Systemic mastocytosis can cause fractures even with normal bone density. This case highlights hip fractures in indolent systemic mastocytosis, emphasizing the need for considering mastocytosis in atypical osteoporosis diagnoses.

Keywords:
fracturehipmastocytosisosteoporosisosteosclerosis

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Area of Science:

  • Bone Metabolism
  • Hematology
  • Endocrinology

Background:

  • Systemic mastocytosis (SM) is associated with increased risk of osteoporosis and fractures.
  • Indolent SM presents unique challenges in fracture risk assessment.
  • Normal bone mineral density does not exclude fracture risk in SM.

Observation:

  • A 48-year-old male with indolent SM experienced a hip fragility fracture.
  • The patient presented with normal bone density but elevated serum tryptase.
  • He developed an anaphylactic reaction post-operatively.

Findings:

  • The fracture occurred despite normal bone density and osteosclerosis.
  • High bone turnover markers (C-terminal telopeptide of collagen type 1, bone-specific alkaline phosphatase) were observed.
  • Increased radiotracer uptake on bone scan indicated high bone turnover.

Implications:

  • Mastocytosis should be considered in the differential diagnosis of osteoporosis, especially with atypical fracture sites like the hip.
  • This case underscores that normal bone density does not preclude fracture risk in SM.
  • Early recognition and management of SM-related bone complications are crucial.