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SIRT1 and thrombosis

Alessandra Bettiol1, Maria Letizia Urban1, Giacomo Emmi1

  • 1Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy.

Frontiers in Molecular Biosciences
|February 2, 2024
PubMed

Insights

Sirtuin 1 (SIRT1) is crucial in regulating thrombosis by influencing inflammation and blood clotting. Targeting SIRT1 shows therapeutic potential for preventing thrombosis, as supported by preclinical and clinical evidence.

Area of Science:

  • Biochemistry
  • Vascular Biology
  • Pharmacology

Background:

  • Thrombosis is a leading global cause of death.
  • Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase involved in cellular regulation.
  • SIRT1 modulates key pathways implicated in thrombosis, including endothelial activation, platelet aggregation, and coagulation.

Purpose of the Study:

  • To review the role of SIRT1 in thrombosis.
  • To critically assess preclinical and clinical studies investigating SIRT1 as a therapeutic target for thrombosis.

Main Methods:

  • Literature review of preclinical (in vitro, in vivo) and clinical studies.
  • Analysis of SIRT1's impact on thrombosis-related pathways.
  • Evaluation of SIRT1's anti-inflammatory and antioxidant effects.

Main Results:

  • SIRT1 plays a significant role in regulating thrombosis.
  • SIRT1 exhibits anti-inflammatory properties, partly through reducing oxidative stress.
  • Targeting SIRT1 has demonstrated therapeutic potential in preventing thrombosis.

Conclusions:

  • SIRT1 is a key regulator in thrombosis pathogenesis.
  • Modulating SIRT1 activity presents a promising therapeutic strategy for thrombosis prevention.
  • Further research is warranted to fully elucidate SIRT1's clinical applications in managing thrombotic disorders.

Keywords:
SIRT1atherosclerosisoxidative stresssirtuinsthrombosis

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