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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Association Between Nonthyroidal Illness Syndrome and Disseminated Intravascular Coagulation in Sepsis
1Departments of Emergency, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, People's Republic of China.
Journal of Inflammation Research
|February 2, 2024
Summary
Nonthyroidal illness syndrome (NTIS) is a significant independent risk factor for disseminated intravascular coagulation (DIC) in sepsis patients. Sepsis patients with both NTIS and DIC face higher mortality rates.
Area of Science:
- Critical Care Medicine
- Endocrinology
- Hematology
Background:
- Sepsis frequently leads to nonthyroidal illness syndrome (NTIS) and disseminated intravascular coagulation (DIC).
- Understanding the relationship between NTIS and DIC in sepsis is crucial for patient outcomes.
Purpose of the Study:
- To investigate the association between NTIS and DIC in adult sepsis patients.
- To evaluate the impact of co-occurring NTIS and DIC on sepsis-related mortality.
Main Methods:
- A cohort of 1219 adult sepsis patients was analyzed from two academic centers.
- Logistic and modified Poisson regression models were used to assess risk factors and mortality.
- Correlation analysis examined relationships between thyroid function and coagulation parameters.
Main Results:
- NTIS was identified as an independent risk factor for developing DIC in sepsis (OR 3.19).
- Sepsis patients with both DIC and NTIS exhibited significantly higher 28-day mortality (23.2% vs 14.0%).
- Thyroid function parameters showed weak correlations with coagulation markers in sepsis.
Conclusions:
- NTIS is a significant independent predictor of DIC in adult sepsis.
- The presence of NTIS in sepsis patients with DIC is associated with increased disease severity and mortality.
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