Significance of tumour budding and invasive characteristics in grading of oral squamous cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Tumour budding and invasion patterns are significant in oral squamous cell carcinoma (OSCC). Incorporating tumour buds into grading systems improves OSCC assessment and prediction of metastasis.
Area Of Science
- Oral pathology
- Cancer research
- Histopathology
Background
- Tumour budding is a recognized morphological marker of tumour invasion.
- Invasive characteristics like depth, mode, and pattern of invasion can predict metastasis.
Purpose Of The Study
- To evaluate the significance of tumour budding and invasion characteristics in oral squamous cell carcinoma (OSCC).
- To assess the impact of these features on OSCC grading.
Main Methods
- Immunohistochemical analysis using pan cytokeratin staining on 34 OSCC tissue samples.
- Observation of tumour budding and invasive patterns under high-power magnification.
Main Results
- Tumour budding and invasive patterns were found to be significant indicators in OSCC.
- A novel grading system based on tumour budding and cell nests showed significant correlation with the WHO grading system.
Conclusions
- Tumour buds are important additional parameters for OSCC grading.
- Invasive patterns, cellular atypia, and stromal content are crucial factors in OSCC assessment.
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