Regulated cell death in glioma: promising targets for natural small-molecule compounds
Mingyu Han1, Sui Li1, Huali Fan1
1West China School of Pharmacy, Sichuan University, Chengdu, China.
Abstract:
Gliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there is no complete cure, and the median survival time is less than one year. The main mechanism of regulated cell death involves organisms coordinating the elimination of damaged cells at risk of tumor transformation or cells hijacked by microorganisms for pathogen replication. This process includes apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis, necrosis, parthanayosis, entosis, lysosome-dependent death, NETosis, oxiptosis, alkaliptosis, and disulfidaptosis. The main goal of clinical oncology is to develop therapies that promote the effective elimination of cancer cells by regulating cell death are the main goal of clinical oncology. Recently, scientists have utilized pertinent regulatory factors and natural small-molecule compounds to induce regulated cell death for the treatment of gliomas. By analyzing the PubMed and Web of Science databases, this paper reviews the research progress on the regulation of cell death and the role of natural small-molecule compounds in glioma. The aim is to provide help for the treatment of glioblastoma.
Insights
This review explores how regulating cell death, including apoptosis and ferroptosis, can combat aggressive brain tumors like glioblastoma. Natural compounds show promise in developing new glioma treatments.
Area of Science:
- Oncology
- Cell Biology
- Pharmacology
Background:
- Gliomas, particularly glioblastoma, are aggressive adult brain tumors with poor prognoses.
- Regulated cell death (RCD) mechanisms are crucial for eliminating damaged or infected cells.
- Current glioblastoma treatments are insufficient, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review research on regulated cell death mechanisms in glioma.
- To examine the role of natural small-molecule compounds in inducing RCD for glioma treatment.
- To provide insights for developing new glioblastoma therapies.
Main Methods:
- Literature review of PubMed and Web of Science databases.
- Analysis of research on various regulated cell death pathways (apoptosis, necroptosis, ferroptosis, etc.).
- Investigation of natural small-molecule compounds targeting RCD in glioma models.
Main Results:
- Multiple RCD pathways are implicated in cellular regulation and cancer.
- Natural small molecules can induce specific RCD pathways relevant to glioma.
- Targeting RCD presents a promising avenue for glioblastoma therapy.
Conclusions:
- Understanding RCD mechanisms is vital for advancing glioma treatment.
- Natural compounds offer a potential source for novel glioblastoma therapeutics.
- Further research into RCD modulation is essential for clinical applications in oncology.
