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Periodontium-Mimicking, Multifunctional Biomass-Based Hydrogel Promotes Full-Course Socket Healing
Yuxuan Guo1, Zijian Shao2, Wenjie Wang2
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Ren Min Nan Rd, Chengdu, Sichuan 610041, China.
Biomacromolecules
|February 2, 2024
Summary
A novel hydrogel, inspired by the periodontium, effectively promotes tooth extraction socket healing. This biomaterial dressing accelerates wound closure, exhibits hemostatic and antibacterial properties, and supports tissue regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Oral Surgery
Background:
- Maintaining tooth-periodontal tissue integration is crucial for alveolar bone stability.
- Tooth extraction disrupts this integration, hindering optimal socket healing.
- Early socket coverage is essential for promoting effective wound healing.
Purpose of the Study:
- To develop a periodontium-mimicking hydrogel for enhanced tooth extraction socket healing.
- To evaluate the efficacy of a novel quaternized methacryloyl chitosan/dopamine-grafted oxidized sodium alginate hydrogel (QDL hydrogel).
Main Methods:
- Fabrication of a QDL hydrogel using biomass-derived chitosan and sodium alginate.
- Blue-light-induced cross-linking for hydrogel formation and application as a wound dressing.
- Assessment of hydrogel properties including mechanical characteristics, adhesion, hemostasis, antibacterial activity, and angiogenesis promotion.
Main Results:
- The QDL hydrogel demonstrated remarkable efficacy in closing irregular tooth extraction wounds.
- Favorable mechanical properties, flexible formability, and strong adhesion were observed.
- The hydrogel exhibited superior hemostatic and antibacterial capabilities, inhibited oral microorganisms, and promoted angiogenesis.
- Gene expression analysis indicated accelerated socket healing due to upregulated wound healing-related genes.
Conclusions:
- The periodontium-mimicking QDL hydrogel shows significant potential as a clinical wound dressing for tooth extraction sockets.
- Its multifunctional properties, including hemostasis, antibacterial action, and promotion of regeneration, support optimal socket healing.
- This biomaterial offers a promising approach to improve post-extraction wound management and accelerate tissue regeneration.
