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Gastrointestinal function in patients with progressive systemic sclerosis.

A Akesson, B Akesson, T Gustafson

    Clinical Rheumatology
    |December 1, 1985
    PubMed
    Summary
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    Progressive systemic sclerosis (PSS) patients often have increased gastric acid secretion, which may contribute to reflux esophagitis. However, increased acid and reflux were not linked to esophageal mycosis in this study.

    Area of Science:

    • Gastroenterology
    • Rheumatology
    • Internal Medicine

    Background:

    • Progressive systemic sclerosis (PSS) commonly involves esophageal dysfunction.
    • Reflux esophagitis is a frequent complication of PSS-related esophageal issues.
    • The relationship between gastric acid secretion and PSS complications requires further investigation.

    Purpose of the Study:

    • To determine if increased gastric acid secretion is associated with reflux esophagitis in patients with PSS.
    • To investigate the prevalence of gastroesophageal reflux, reflux esophagitis, and esophageal mycosis in PSS patients.
    • To assess for bacterial overgrowth and malabsorption in PSS patients using non-invasive methods.

    Main Methods:

    • Pentagastrin-stimulated gastric acid secretion measurement.

    Related Experiment Videos

  • Assessment of gastroesophageal reflux, reflux esophagitis, and esophageal mycosis.
  • Non-invasive tests for bacterial overgrowth (bile acid deconjugation, 14C-xylose degradation) and fat malabsorption (triolein breath test).

    • Main Results:

    • Gastroesophageal reflux was observed in 12/24 patients, reflux esophagitis in 9/24, and esophageal mycosis in 8/24.
    • Increased gastric acid secretion (54%) was noted, tending to be higher in patients with esophagitis.
    • Bacterial overgrowth was indicated in 3 patients, and malabsorption in 7 patients; nutritional status was generally normal.

    Conclusions:

    • Increased gastric acid secretion may be linked to reflux esophagitis in PSS patients.
    • Esophageal mycosis appeared less common in patients with both reflux and increased acid secretion.
    • Non-invasive methods revealed evidence of bacterial overgrowth and malabsorption in a subset of PSS patients.