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Updated: Jul 4, 2025
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
Polyphenols and their nanoformulations as potential antibiofilm agents against multidrug-resistant pathogens
Modawy Em Elkhalifa1,2, Muhammad Ashraf3, Alshebli Ahmed1,2
1Public Health Department, Health Sciences College at Al-Leith, Umm Al-Qura University, Al leith, KSA.
Abstract:
The emergence of multidrug-resistant (MDR) pathogens is a major problem in the therapeutic management of infectious diseases. Among the bacterial resistance mechanisms is the development of an enveloped protein and polysaccharide-hydrated matrix called a biofilm. Polyphenolics have demonstrated beneficial antibacterial effects. Phenolic compounds mediate their antibiofilm effects via disruption of the bacterial membrane, deprivation of substrate, protein binding, binding to adhesion complex, viral fusion blockage and interactions with eukaryotic DNA. However, these compounds have limitations of chemical instability, low bioavailability, poor water solubility and short half-lives. Nanoformulations offer a promising solution to overcome these challenges by enhancing their antibacterial potential. This review summarizes the antibiofilm role of polyphenolics, their underlying mechanisms and their potential role as resistance-modifying agents.
Insights
Polyphenolics combat biofilms, a major challenge in treating multidrug-resistant (MDR) infections. Nanoformulations enhance these compounds
Area of Science:
- Microbiology
- Pharmacology
- Materials Science
Background:
- Multidrug-resistant (MDR) pathogens pose a significant threat to infectious disease treatment.
- Bacterial biofilms, a matrix of proteins and polysaccharides, contribute to antimicrobial resistance.
- Polyphenolics show promise in combating bacterial infections and biofilms.
Purpose of the Study:
- To review the antibiofilm activity of polyphenolics.
- To elucidate the mechanisms by which polyphenolics exert their antibiofilm effects.
- To explore the potential of nanoformulations in enhancing polyphenolic efficacy against biofilms.
Main Methods:
- Literature review of studies on polyphenolics and biofilms.
- Analysis of reported mechanisms of antibiofilm action.
- Evaluation of nanoformulation strategies for polyphenolics.
Main Results:
- Polyphenolics disrupt bacterial membranes, inhibit adhesion, and interfere with biofilm formation.
- Limitations of polyphenolics include poor solubility, bioavailability, and stability.
- Nanoformulations can overcome these limitations, enhancing antibacterial and antibiofilm potential.
Conclusions:
- Polyphenolics are effective antibiofilm agents with diverse mechanisms.
- Nanoformulation is a viable strategy to improve polyphenolic delivery and efficacy.
- Polyphenolics, especially when nanoformulated, show potential as resistance-modifying agents against MDR pathogens.
