Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stine Brændegaard Winther1, Gabor Liposits2, Trine L Jørgensen1

  • 1Onkologisk Afdeling, Odense Universitetshospital.

Ugeskrift for Laeger
|February 2, 2024
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of older adults with colorectal cancer - The state-of-the-art in 2026.

Journal of geriatric oncology·2026
Same author

Association between Geriatric 8 frailty and overall survival, treatment intensity, and treatment tolerance in older patients with cancer (PROGNOSIS-G8).

Journal of geriatric oncology·2026
Same author

Circulating tumor DNA-guided response evaluation in patients with previously treated gastroesophageal adenocarcinoma.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·2026
Same author

Management of colorectal cancer in older adults: an expert panel recommendation to guide daily clinical practice.

The lancet. Gastroenterology & hepatology·2026
Same author

Survival benefit of oral systemic monotherapy in previously treated metastatic colorectal cancer: a meta-analysis.

The oncologist·2026
Same author

Neoadjuvant Single-Cycle Pembrolizumab for Stage I-III MMR-Deficient Colon Cancer: The RESET-C Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026

The number of older cancer patients is rising, but clinical trials often exclude them, especially frail individuals. More research is needed to guide cancer treatment for this growing population.

Area of Science:

  • Geriatric Oncology
  • Clinical Trial Design
  • Cancer Therapeutics

Background:

  • Demographic shifts are increasing the incidence of cancer in older adults.
  • Current systemic cancer treatments are complex and evolving.
  • Older patients, particularly those who are frail, are underrepresented in clinical trials.

Approach:

  • This review synthesizes existing knowledge on treating older cancer patients.
  • It highlights the limitations of current data, often derived from fit older patients in pooled analyses.
  • The review emphasizes the scarcity of randomized trials specifically including frail older patients.

Key Points:

  • Older adults with cancer are a growing population with unique treatment needs.
  • Clinical trials frequently fail to include diverse older populations, especially frail individuals.

Related Experiment Videos

  • Evidence for optimal cancer treatment in frail older patients is limited.

    • Conclusions:

    • There is a critical unmet need for clinical trials focused on older and frail cancer patients.
    • Current treatment strategies for older cancer patients lack robust evidence due to trial underrepresentation.
    • Future research must prioritize the inclusion and study of vulnerable older populations in oncology trials.