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Leaky Scanning

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
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Related Experiment Video

Updated: Jul 4, 2025

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

Published on: July 29, 2021

Structure-based approaches against COVID-19.

Ta-Chou Huang^1,2, Kung-Hao Liang^1,3,4, Tai-Jay Chang^1,5,6

¹Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Journal of the Chinese Medical Association : JCMA

|February 2, 2024

Summary

Structure-based approaches, including classical and AI-integrated methods, have been crucial for understanding SARS-CoV-2. These techniques accelerate the development of COVID-19 vaccines and antiviral drugs.

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Last Updated: Jul 4, 2025

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

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Published on: July 29, 2021

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

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Published on: June 28, 2013

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

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Published on: June 6, 2025

Area of Science:

Structural biology
Virology
Drug discovery

Background:

The COVID-19 pandemic caused by SARS-CoV-2 significantly impacted global health.
Understanding the structure of SARS-CoV-2 and its interactions is vital for therapeutic development.

Conclusions:

Structure-based approaches are essential for understanding and controlling SARS-CoV-2.
Continued advancements in structural biology and AI will drive future COVID-19 research and treatment.
These methods are pivotal for developing effective vaccines and antiviral drugs.