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Updated: Jul 4, 2025
Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
Evaluating the effectiveness of inflammatory markers in pediatric open globe injury using a modified pediatric ocular
Özlem Özcanlı Çay1, Eyyup Karahan2, Mehmet Murat Uzel2
1Department of Pediatrics, Balıkesir City Hospital, Balıkesir-Türkiye.
Insights
The Modified Pediatric Ocular Trauma Score effectively assesses prognosis in pediatric Open Globe Injury (OGI). Higher Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) correlate with poorer outcomes in OGI patients.
Area of Science:
- Ophthalmology
- Pediatric Medicine
- Trauma Surgery
Background:
- Pediatric Open Globe Injury (OGI) presents significant challenges in prognosis assessment.
- The Modified Pediatric Ocular Trauma Score (MPOTS) is a tool used to evaluate OGI severity.
- Inflammatory markers like Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) may indicate injury impact.
Purpose of the Study:
- To evaluate the efficacy of the Modified Pediatric Ocular Trauma Score (MPOTS) in pediatric OGI cases.
- To investigate the relationship between NLR and PLR levels and the prognosis determined by MPOTS.
- To explore potential biomarkers for predicting outcomes in pediatric OGI.
Main Methods:
- Retrospective analysis of pediatric patients diagnosed with Open Globe Injury (OGI).
- Data collection included demographics, injury specifics, visual acuities, and NLR/PLR values.
- Patients were stratified into three risk groups (Grade I, II, III) based on MPOTS scores.
Main Results:
- A total of 22 pediatric OGI patients were analyzed.
- Higher risk groups (Grade I) showed longer injury-to-surgery duration and more globe ruptures.
- Elevated NLR and PLR values were observed in the high-risk group, correlating negatively with MPOTS scores.
Conclusions:
- The MPOTS is a practical and effective tool for assessing prognosis in pediatric OGI.
- Increased NLR and PLR levels are associated with poorer outcomes in pediatric OGI patients.
- NLR and PLR may serve as valuable indicators for predicting OGI prognosis in children.
Background:
This study aims to assess pediatric patients with Open Globe Injury (OGI) using the Modified Pediatric Ocular Trauma Score (MPOTS) and to investigate the correlation between Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lympho-cyte ratio (PLR) parameters with the prognosis determined by MPOTS.
Methods:
In this retrospective study, we included pediatric patients with OGI. Recorded data encompassed demographic details, injury type, duration from injury to surgery, complete ophthalmological examinations, initial and final visual acuities, anterior segment and fundus findings, and NLR and PLR values. Patients were categorized into three groups based on their MPOTS scores: Grade I (≤30 points), indicating high risk; Grade II (35-65 points), moderate risk; and Grade III (≥70 points), low risk. Differences between categories were statistically evaluated.
Results:
The study comprised 22 patients. In Category I, the duration from injury to surgery was longer (p=0.018). The most common injury type in this category was globe rupture, occurring in four (50%) patients, with a significant difference noted between the groups (p=0.041). Category I exhibited lower final visual acuity and higher NLR and PLR values compared to the other categories (p<0.050 for all values). Both NLR and PLR demonstrated significant negative correlations with MPOTS (respectively, r=-0.869, p<0.001; r=-0.809, p<0.001).
Conclusion:
The Modified Pediatric Ocular Trauma Score is an effective and practical method for assessing the prognosis of pediatric patients with Open Globe Injury (OGI). Furthermore, there is evidence indicating a negative correlation between MPOTS and the increase in NLR and PLR values that often follows OGI in this patient population.
