Prognostic value of combined preoperative inflammatory marker neutrophil-lymphocyte ratio and platelet distribution width in patients with gallbladder carcinoma

Fei Liu ¹, Jun-Ke Wang ¹, Wen-Jie Ma ¹

⁰Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.

Langenbeck's Archives of Surgery +

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February 2, 2024

View abstract on PubMed

Summary

The combination of neutrophil-lymphocyte ratio (NLR) and platelet distribution width (PDW) can predict gallbladder cancer prognosis. Elevated NLR and PDW indicate a poorer outlook for GBC patients.

Area Of Science

Oncology
Hematology
Surgical Oncology

Background

Neutrophil-lymphocyte ratio (NLR) and platelet distribution width (PDW) are linked to adverse outcomes in various cancers.
Their combined prognostic value in gallbladder carcinoma (GBC) remains underexplored.

Purpose Of The Study

To investigate the prognostic significance of combining preoperative NLR and PDW in GBC patients.
To evaluate if this combination improves prognostic accuracy compared to individual markers.

Main Methods

Retrospective analysis of 287 GBC patients undergoing curative surgery.
Determination of optimal NLR and PDW cutoff values using ROC curves.
Kaplan-Meier and Cox regression analyses for overall survival (OS) assessment.

Main Results

Optimal cutoff values were NLR=3.00 and PDW=14.76.
Higher NLR and PDW levels correlated with significantly worse OS.
Multivariate analysis confirmed NLR and PDW as independent prognostic factors for GBC.
Combined NLR and PDW demonstrated a higher AUC (0.676) than NLR (0.665) or PDW (0.632) alone.

Conclusions

The combined assessment of NLR and PDW serves as a potent prognostic biomarker for GBC.
This combination offers superior prognostic prediction for GBC patients compared to using NLR or PDW individually.

Keywords:

Gallbladder carcinoma Neutrophil–lymphocyte ratio Platelet distribution width Prognosis