Ferroptosis and aerobic training in ageing
Negin Kordi1, Ali Saydi1, Sajad Karami2
1Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
Clinical Hemorheology and Microcirculation
|February 2, 2024
Summary
Ferroptosis, a cell death process linked to aging and obesity, impacts diseases like heart failure. Understanding its mechanisms, especially concerning physical activity, is key for potential therapies.
Area of Science:
- Biochemistry and Molecular Biology
- Cellular Biology
- Physiology
Background:
- Ferroptosis, a regulated cell death pathway, is implicated in various diseases, including cardiovascular conditions, through metabolic dysregulation.
- Aging and obesity are associated with altered substrate metabolism, potentially exacerbating ferroptosis.
- Understanding ferroptosis mechanisms is crucial due to its impact on elderly mortality and disease pathogenesis.
Purpose of the Study:
- To elucidate the molecular mechanisms governing ferroptosis.
- To investigate the influence of aging and obesity on ferroptosis.
- To explore the role of physical activity in modulating ferroptosis.
Main Methods:
- Review of current literature on ferroptosis signaling pathways.
- Analysis of metabolic alterations in aging and obesity relevant to ferroptosis.
- Examination of studies investigating physical activity's impact on cellular metabolism and ferroptosis.
Main Results:
- Ferroptosis is intricately linked to lipid, amino acid, and iron metabolism.
- Age-related and obesity-induced metabolic changes may promote ferroptosis.
- Physical activity demonstrates potential to modulate ferroptosis through metabolic regulation.
Conclusions:
- Ferroptosis suppression is a promising therapeutic strategy for age-related diseases and conditions like sarcopenia and CNS disorders.
- Further research is needed to fully comprehend the complex pathological and biological roles of ferroptosis.
- Physical activity represents a modifiable factor influencing ferroptosis, warranting deeper investigation.
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