INDIVIDUAL ARTICLE: Antibiotic Stewardship in Acne: 2023 Update

Area of Science:

• Dermatology
• Microbiology
• Pharmacology

Background:

• Topical and oral antibiotics are standard treatments for acne vulgaris, targeting Cutibacterium acnes.
• Widespread antibiotic use has led to a global increase in antibiotic resistance in C. acnes and other bacteria.
• Rising acne prevalence and antibiotic use necessitate antibiotic stewardship to preserve treatment efficacy.

Purpose of the Study:

• To provide an updated review of Cutibacterium acnes resistance to common acne antibiotics.
• To emphasize the importance of benzoyl peroxide in managing and preventing antibiotic resistance in acne treatment.

Main Methods:

• Literature review of antibiotic resistance patterns in Cutibacterium acnes.
• Analysis of the role of benzoyl peroxide in acne treatment regimens.

Main Results:

• Significant C. acnes resistance to commonly prescribed antibiotics has been documented.
• Benzoyl peroxide demonstrates efficacy in monotherapy and combination therapy for acne.
• Incorporating benzoyl peroxide can mitigate antibiotic resistance development.

Conclusions:

• Urgent adoption of antibiotic stewardship is crucial for maintaining acne treatment effectiveness.
• Benzoyl peroxide is a key agent for overcoming and preventing antibiotic resistance in acne vulgaris.
• Combination therapy or benzoyl peroxide monotherapy should be considered to combat resistance.