Does hormone therapy impact cognition in patients with prostate cancer? A systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Hormone therapy for prostate cancer may increase perceived cognitive difficulties, but this systematic review found no conclusive evidence of a decline in objective cognitive performance. Further research is needed to understand these impacts.
Area Of Science
- Oncology
- Neuroscience
- Geriatrics
Background
- Hormone therapy is a common prostate cancer treatment.
- Cognitive impairment is a potential side effect, impacting elderly patients' autonomy.
- Previous research on hormone therapy's cognitive effects yielded conflicting results.
Purpose Of The Study
- To systematically review and meta-analyze the longitudinal impact of hormone therapy on both objective and subjective cognition in prostate cancer patients.
- To synthesize existing evidence and provide a clearer understanding of cognitive changes during treatment.
Main Methods
- A comprehensive literature search was conducted across PubMed, Web of Science, and PsycINFO.
- Studies longitudinally assessing cognition in patients receiving androgen-deprivation therapy (ADT) and new-generation hormone therapy were included.
- A meta-analysis aggregated scores into six objective and one subjective cognitive domains, using a random effects model to compute effect sizes.
Main Results
- Twenty studies (1440 patients) were included in the review; 15 (1093 patients) in the meta-analysis.
- A significant decline in subjective cognition was observed with ADT and new-generation hormone therapy (g = -0.44, p = .03).
- No significant decline in objective cognition was found, with small effect sizes across all domains (g = -0.02 to 0.18). Significant heterogeneity was noted in objective cognitive domains.
Conclusions
- This meta-analysis provides evidence that ADT and new-generation hormone therapy negatively impact subjective cognition.
- There is no conclusive evidence of a decline in objective cognitive performance during hormone therapy.
- High heterogeneity in objective cognitive research highlights the need for standardized methodologies in prostate cancer studies.
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