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Related Concept Videos

GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins, also known...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins, also known...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
Two...
Correspondence Bias01:17

Correspondence Bias

Correspondence bias, also referred to as the fundamental attribution error, describes the tendency to attribute another person’s behavior to internal characteristics rather than situational influences. This cognitive bias leads individuals to overlook external factors that may be influencing actions, thereby fostering potentially inaccurate assessments of others’ intentions and dispositions.Empirical Evidence for Correspondence BiasResearch has consistently demonstrated the prevalence of...

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Related Experiment Video

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Using the optokinetic response to study visual function of zebrafish
08:59

Using the optokinetic response to study visual function of zebrafish

Published on: February 2, 2010

Reply to Z. Gao et al

Carine El Sissy1, Amos Kirilovsky1, Soledad Iseas1

  • 1Carine El Sissy, MD, PhD and Amos Kirilovsky, PhD, INSERM, Laboratory of Integrative Cancer Immunology, Paris, France, Equipe Labellisée Ligue Contre le Cancer, Paris, France, Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France, Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France; Soledad Iseas, MD, PhD, Oncology Unit, Hospital Paris Saint-Joseph, Paris, France; Christine Lagorce Pagès, MD, PhD, INSERM, Laboratory of Integrative Cancer Immunology, Paris, France, Equipe Labellisée Ligue Contre le Cancer, Paris, France, Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France, Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France, Department of Pathology, AP-HP, Georges Pompidou European Hospital, Paris, France; and Guy Zeitoun, MD and Franck Pagès, MD, PhD, INSERM, Laboratory of Integrative Cancer Immunology, Paris, France, Equipe Labellisée Ligue Contre le Cancer, Paris, France, Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France, Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|February 2, 2024
PubMed
Summary

No abstract available in PubMed .

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