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Functions of Sialyltransferases in gynecological malignancies: A systematic review
Siyuan Sun1, Zhenying Yang1, Mehrsa Majdaeen2
1Department of Gynecology, The Central Hospital of Yongzhou, Yongzhou 425000, China.
Introduction:
The biosynthesis of tumor-associated sialoglycans involves Sialyltransferases expressed in cancer cells differentially. The current review aspires to bridge the existing knowledge gaps by consolidating evidence regarding the role of Sialyltransferases in gynecological malignant tumors (ovarian, cervix, endometrial, and breast).
Methods:
In this systematic review, we searched databases, including PubMed, Embase, Web of Science, Scopus and Cochrane Library. Twenty-two high-quality articles were selected out of 559 researched studies using radiomics quality score (RQS) tools.
Results:
Our findings indicated that 7 articles were related to Sialyltransferases in ovarian cancer, in which 6 studies was examined only ST6Gal-I and one study examined the ST3Gal-I, ST3Gal-II, ST3Gal-III, ST3Gal-IV, ST3Gal-VI, and ST3Gal-6. In addition, 5 articles were related to Sialyltransferases in cervix cancer (ST6Gal-I), 3 articles to endometrial cancer (ST6Gal-I, ST3Gal-III, ST3Gal-IV, and ST3Gal-6), and 7 articles to breast cancer (ST6Gal-I gene in 5 studies, ST6GAL-II gene in one study, and ST8SIA1 and ST3GAL-V genes in one study).
Conclusion:
ST6Gal-I gene expression occurs at a high speed in ovarian, cervix, endometrial, and breast cancers, leading to metastasis to distant cells, cell destruction, cell invasion, and reduced patient survival.
Insights
Sialyltransferases (STs) are key in tumor-associated sialoglycans. High ST6Gal-I gene expression in gynecological cancers promotes metastasis and reduces survival.
Area of Science:
- Biochemistry
- Oncology
- Glycomics
Background:
- Tumor-associated sialoglycans are synthesized by Sialyltransferases (STs) differentially expressed in cancer cells.
- This review consolidates evidence on ST roles in gynecological cancers (ovarian, cervix, endometrial, breast).
Approach:
- Systematic review of PubMed, Embase, Web of Science, Scopus, and Cochrane Library.
- Selection of 22 high-quality articles from 559 studies using radiomics quality score (RQS).
Key Points:
- Ovarian cancer: 7 articles, primarily ST6Gal-I (6 studies).
- Cervix cancer: 5 articles, ST6Gal-I.
- Endometrial cancer: 3 articles, ST6Gal-I, ST3Gal-III, ST3Gal-IV, ST3Gal-6.
- Breast cancer: 7 articles, ST6Gal-I (5 studies), ST6GAL-II, ST8SIA1, ST3GAL-V.
Conclusions:
- Elevated ST6Gal-I gene expression is common in ovarian, cervix, endometrial, and breast cancers.
- High ST6Gal-I expression correlates with increased metastasis, invasion, and reduced patient survival.
