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Cryo-electron Microscopy

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...

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Updated: Jul 4, 2025

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

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Cryo-EM research in India.

Arun K Shukla, Manidipa Banerjee, Appu K Singh

Structure (London, England : 1993)

|February 2, 2024

Summary

This summary is machine-generated.

This collection highlights India

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Area of Science:

Structural biology research

Background:

Celebrating 50 years of Cell Press and a special issue on structural biology.
Focusing on the rapid advancements in cryo-electron microscopy (cryo-EM) research within India.

Purpose of the Study:

To showcase the progress of cryo-EM related research in India.
To provide insights into the work of Indian structural biologists.
To map the national cryo-EM facilities available across the country.

Main Methods:

Collection of 'Voices' from structural biologists.
Introduction of individual research projects.
Description of national cryo-electron microscopy facilities.

Main Results:

Compilation of research highlights from Indian structural biologists.
Overview of the current state and capabilities of cryo-EM in India.

Conclusions:

Demonstrates significant growth in India's cryo-EM research landscape.
Emphasizes the importance of national facilities in advancing structural biology.