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Bioprinting functional neural networks.

Stephanie M Willerth1

  • 1Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada; Division of Medical Sciences, University of Victoria, 3800 Finnerty Road, Victoria, BC V8W 2Y2, Canada; Axolotl Biosciences, 3800 Finnerty Road, Victoria, BC V8W 2Y2, Canada; Centre for Advanced Materials and Technologies, University of Victoria, 3800 Finnerty Road, Victoria, BC V8W 2Y2, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Cell Stem Cell
|February 2, 2024
PubMed
Summary

Stem cell-derived 3D bioprinting creates functional human neural tissue models. This technology allows researchers to study healthy and diseased neural networks for biological insights.

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Area of Science:

  • Biotechnology
  • Neuroscience
  • Tissue Engineering

Background:

  • Stem cells offer a promising source for generating diverse human cell types.
  • Three-dimensional (3D) bioprinting is an emerging technology for creating complex biological structures.

Purpose of the Study:

  • To demonstrate the application of 3D bioprinting using stem cells for modeling human neural tissues.
  • To create functional neural networks in vitro for studying neurological conditions.

Main Methods:

  • Utilizing stem cells as building blocks for bioprinting.
  • Employing 3D printing techniques to assemble cells into neural tissue constructs.
  • Culturing and characterizing the engineered neural tissues.

Main Results:

  • Successful fabrication of mature human neural tissue models.
  • Demonstration of functional neural networks within the 3D printed constructs.
  • Establishment of a platform for modeling both healthy and diseased neural states.

Conclusions:

  • 3D bioprinting with stem cells is a viable strategy for engineering functional human neural tissues.
  • This approach provides a powerful tool for advancing neuroscience research and disease modeling.