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Published on: July 23, 2016

Intraocular penetration of fusidic acid with topical Fucithalmic

S Hansen

    European Journal of Drug Metabolism and Pharmacokinetics
    |October 1, 1985
    PubMed

    Insights

    Fucithalmic, a new eye antibiotic suspension, effectively penetrates the eye. Twice-daily dosing achieves therapeutic levels in aqueous humor, comparable to systemic administration for treating eye infections.

    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Microbiology

    Background:

    • Introduction of Fucithalmic, a novel 1% microcrystalline suspension of fusidic acid.
    • Fusidic acid is an established antistaphylococcal antibiotic.
    • Need for effective topical ocular antibiotics for anterior segment infections.

    Purpose of the Study:

    • To investigate the ocular penetration of Fucithalmic in patients undergoing cataract surgery.
    • To determine the aqueous humor concentrations of fusidic acid following single and repeated doses.
    • To compare topical Fucithalmic ocular concentrations with systemically administered fusidic acid.

    Main Methods:

    • Twenty patients scheduled for cataract extraction participated in the study.
    • A single dose of Fucithalmic 1% suspension was administered.
    • Aqueous humor samples were collected to measure fusidic acid levels at specified time points.

    Main Results:

    • A single dose achieved median aqueous humor antibiotic levels of 0.3 mcg/ml, sustained for over 12 hours.
    • Repeated dosing resulted in significantly higher median levels (0.8 mcg/ml), suggesting a cumulative effect.
    • Fusidic acid demonstrated penetration across the corneal-aqueous barrier.

    Conclusions:

    • Topical Fucithalmic effectively penetrates the anterior chamber of the eye.
    • Twice-daily administration yields aqueous concentrations comparable to or exceeding those from recommended systemic doses.
    • Fucithalmic shows promise as a topical treatment for ocular infections requiring adequate antibiotic levels.

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