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TGR5 signalling in heart and brain injuries: focus on metabolic and ischaemic mechanisms

Nan Xu1, Yufeng He2, Chunyu Zhang2

  • 1Department of Cardiology, The First People's Hospital of Neijiang, Neijiang, China.

Neurobiology of Disease
|February 2, 2024
PubMed

Insights

Takeda protein-coupled receptor 5 (TGR5) regulates metabolism in the heart and brain. Understanding TGR5

Area of Science:

  • Physiology
  • Metabolic Regulation
  • Neurocardiology

Background:

  • The heart and brain are vital organs with complex interconnections, forming the "heart-brain axis."
  • Metabolic dysregulation and inflammation significantly impact neuronal and cardiac function.
  • Takeda protein-coupled receptor 5 (TGR5) is a key metabolic regulator.

Purpose of the Study:

  • To explore the role of TGR5 in heart and brain development and injury.
  • To investigate TGR5's function as a metabolic regulator in these organs.
  • To identify TGR5 as a potential therapeutic target for metabolic and ischemic diseases.

Main Methods:

  • Literature review and synthesis of existing research on TGR5.
  • Analysis of TGR5's involvement in metabolic pathways.
  • Examination of TGR5's impact on cardiac and neuronal tissues.

Main Results:

  • TGR5 influences energy, bile acid, glucose, and lipid metabolism.
  • Inflammation is a critical factor in TGR5-mediated heart and brain processes.
  • TGR5 plays a role in both organ development and response to injury.

Conclusions:

  • TGR5 is a crucial metabolic regulator in the heart and brain.
  • Targeting TGR5 may offer novel therapeutic strategies for heart and brain diseases.
  • Further research into the heart-brain axis and TGR5 is warranted.

Keywords:
BrainHeartInjuryIschemicMetabolicTGR5

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