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Lignin derivatives-based hydrogels for biomedical applications.

Elham Khadem1, Mohsen Ghafarzadeh1, Mahshid Kharaziha1

  • 1Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.

International Journal of Biological Macromolecules
|February 2, 2024
PubMed
Summary

Lignin, a renewable polymer, shows promise for biomedical uses. Modifications enhance lignin hydrogels for applications in tissue engineering, drug delivery, and wearable electronics.

Keywords:
Biomedical applicationsChemical modificationsLignin hydrogels

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Renewable Resources

Background:

  • Lignin, a component of lignocellulosic biomass, is a cost-effective, biocompatible, and eco-friendly alternative to petroleum-based polymers.
  • Its inherent antioxidant and antimicrobial properties make it attractive for value-added products.
  • Lignin's chemical structure requires modification to achieve desired properties for biodegradable hydrogels in biomedical applications.

Purpose of the Study:

  • To review recent modification approaches for creating lignin-based hydrogels.
  • To examine current applications of lignin hydrogels in various fields.
  • To discuss challenges and future directions for developing advanced lignin hydrogels.

Main Methods:

  • Review of chemical and physical modification strategies for lignin.
  • Analysis of literature on lignin hydrogel applications.
  • Identification of challenges and future research needs.

Main Results:

  • Lignin hydrogels can be synthesized through various chemical and physical crosslinking methods.
  • Applications include tissue engineering scaffolds, drug delivery systems, wound dressings, biosensors, and wearable electronics.
  • Successful implementation requires tailored modifications to meet specific performance criteria.

Conclusions:

  • Lignin-based hydrogels offer versatile and sustainable solutions for biomedical and electronic applications.
  • Further research into modification techniques and property optimization is crucial for unlocking their full potential.
  • Addressing current challenges will pave the way for innovative lignin hydrogel development.