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Updated: Jul 4, 2025
08:30
Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
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von Willebrand disease: A guide for the internist
Varinder Kaur1, Omar Elghawy2, Saarang Deshpande2
1Associate Professor, Department of Internal Medicine, Division of Hematology and Oncology, University of Virginia, Charlottesville, VA vk4q@virginia.edu.
Cleveland Clinic Journal of Medicine
|February 2, 2024
Summary
Von Willebrand disease (VWD) is an inherited bleeding disorder caused by insufficient or defective von Willebrand factor (VWF). Understanding VWF pathophysiology is key for diagnosing and managing VWD's diverse clinical presentations.
Area of Science:
- Hematology
- Genetics
- Internal Medicine
Background:
- Von Willebrand disease (VWD) is the most prevalent inherited bleeding disorder.
- It arises from quantitative or qualitative defects in von Willebrand factor (VWF).
- The complex pathophysiology necessitates a thorough understanding for accurate diagnostic interpretation.
Purpose of the Study:
- To review the pathophysiology of VWD.
- To outline the different subtypes of VWD.
- To discuss diagnostic testing and management strategies for VWD.
Main Methods:
- Literature review of VWD pathophysiology.
- Analysis of VWD subtypes and their clinical presentations.
- Summary of diagnostic approaches and management guidelines.
Main Results:
- VWD results from insufficient or defective VWF.
- Subtypes of VWD have distinct presentations.
- Management varies from general internist care to hematologist consultation.
Conclusions:
- A comprehensive understanding of VWD pathophysiology is crucial.
- Accurate diagnosis relies on understanding subtypes and appropriate testing.
- Effective management requires tailored approaches for mild to severe cases.
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