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Updated: Jul 4, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

Neuromodulation in migraine.

Karissa N Arca¹, Giorgio Lambru², Amaal J Starling¹

¹Mayo Clinic Arizona, Department of Neurology, Scottsdale, AZ, United States.

Handbook of Clinical Neurology

|February 2, 2024

Summary

This summary is machine-generated.

Neuromodulation offers advanced therapeutic options for migraine treatment by altering nerve activity. Both invasive and noninvasive techniques target central or peripheral nervous systems to reduce migraine frequency and severity.

Keywords:

Migraine Neuromodulation Occipital nerve Spinal cord stimulation Stimulation Supraorbital nerve Transcranial Vagus nerve

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Area of Science:

Neurology
Biomedical Engineering

Background:

Migraine treatment is evolving with new insights into its pathophysiology.
Therapeutic neuromodulation involves altering nerve activity via targeted stimuli.
Neuromodulation offers advanced therapeutic strategies for migraine management.

Approach:

Exploration of central and peripheral neuronal targets for migraine relief.
Development of both invasive and noninvasive neuromodulation techniques.
Utilizing electrical stimulation or chemical agents for targeted neurological intervention.

Key Points:

Noninvasive central neuromodulation shows promise with a low side effect profile and strong evidence from sham-controlled trials.
Noninvasive peripheral neuromodulation devices are accessible (over-the-counter or prescription) and effective for acute and preventive migraine treatment.
Invasive techniques like cranial nerve stimulation and spinal cord stimulation are options for refractory cases.

Conclusions:

Neuromodulation techniques provide significant benefits for patients with complex or refractory migraines.
These methods are suitable for individuals preferring non-medication options or experiencing adverse effects from current medications.
Neuromodulation represents a growing field with diverse applications in migraine therapeutics.