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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

Menstrually associated migraine.

Eleonora De Matteis¹, Raffaele Ornello¹, Simona Sacco¹

¹Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Handbook of Clinical Neurology

|February 2, 2024

Summary

Menstrually related migraine, affecting many women, is driven by hormonal changes. Effective acute treatments include NSAIDs and triptans, with prevention strategies focusing on short-term relief.

Keywords:

CGRP Estrogens Hormonal treatments Menstrually related migraine Menstruation NSAIDs Pure menstrual migraine Triptans

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Area of Science:

Neurology
Gynecology
Pharmacology

Background:

Menstrually related migraine impacts 35-54% of women of reproductive age, characterized by attacks occurring outside perimenstrual periods.
Hormonal fluctuations, genetic predisposition, and altered brain connectivity are key pathophysiological drivers.
These attacks are often severe and disabling, necessitating targeted management strategies.

Approach:

Review of acute treatments including NSAIDs and triptans, particularly for those with dysmenorrhea.
Evaluation of preventive strategies, including short-term NSAID/triptan use and hormonal therapies.
Exploration of emerging treatments targeting CGRP, such as gepants, for both acute and preventive care.

Key Points:

Acute management involves NSAIDs and triptans.
Short-term prevention with NSAIDs and triptans is effective, but long-term data are lacking.
Hormonal treatments show limited evidence, while CGRP inhibitors (gepants) are promising.
Understanding comorbidities is crucial for effective patient management.

Conclusions:

Menstrually related migraine requires specific management due to its severity and hormonal triggers.
Current acute treatments are established, while preventive options need further investigation for long-term efficacy.
Gepants represent a promising therapeutic avenue for both acute and preventive treatment of menstrually related migraine.