Related Experiment Video
Updated: Jul 4, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.2K
The evolving concept of multimorbidity and migraine
Claudia Altamura1, Gianluca Coppola2, Fabrizio Vernieri1
1Research Unit of Headache and Neurosonology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Handbook of Clinical Neurology
|February 2, 2024
Summary
Migraine often co-occurs with other conditions due to shared genetics and physiological responses. Effective migraine management requires a multidisciplinary approach addressing comorbidities and individual patient needs.
Area of Science:
- Neurology
- Neuroscience
- Immunology
Background:
- Migraine exhibits high prevalence and clinical overlap with neurological, psychiatric, cardiovascular, gastrointestinal, metabolic, and immunological disorders.
- These comorbidities often co-occur with migraine, suggesting multifaceted underlying mechanisms and bidirectional links.
- Shared genetic factors and pathological processes like altered energy demands, network hyperexcitability, and inflammation contribute to migraine comorbidity.
Conclusions:
- Migraine management is complex due to its frequent comorbidities and shared pathophysiological pathways.
- Standard migraine therapies may have systemic side effects, while some treatments can positively impact comorbid conditions.
- A multidisciplinary approach is essential for identifying and mitigating risk factors, managing comorbidities, and tailoring individualized migraine therapies.
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